Evan D Kharasch Selected Research

fenobam

1/2020	The metabotropic glutamate receptor 5 negative allosteric modulator fenobam: pharmacokinetics, side effects, and analgesic effects in healthy human subjects.
9/2009	The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine.

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Evan D Kharasch Research Topics

Disease

14	Pain (Aches) 01/2020 - 12/2003
14	Miosis 01/2019 - 03/2003
8	Neoplasms (Cancer) 12/2019 - 12/2003
6	Renal Cell Carcinoma (Grawitz Tumor) 01/2019 - 01/2011
5	Kidney Neoplasms (Kidney Cancer) 12/2019 - 05/2010
4	Opioid-Related Disorders (Opiate Addiction) 01/2020 - 12/2006
4	Respiratory Insufficiency (Respiratory Failure) 01/2019 - 09/2004
4	Cancer Pain 09/2004 - 12/2003
3	HIV Infections (HIV Infection) 10/2019 - 12/2006
2	Chronic Pain 10/2021 - 03/2017
2	Treatment-Resistant Depressive Disorder 04/2021 - 01/2019
2	Neuralgia (Stump Neuralgia) 01/2021 - 07/2018
2	Postoperative Pain 01/2019 - 12/2011
2	Hypersensitivity (Allergy) 07/2018 - 09/2009
2	Sickle Cell Anemia (Hemoglobin S Disease) 01/2017 - 12/2016
2	Kidney Diseases (Kidney Disease) 05/2013 - 06/2010
2	Inflammation (Inflammations) 09/2009 - 02/2005
2	Necrosis 10/2006 - 12/2005
2	Breakthrough Pain 09/2004 - 12/2003
1	Fibrosis (Cirrhosis) 01/2020
1	Hyperalgesia 01/2020
1	Obstructive Sleep Apnea 01/2019
1	Zika Virus Infection 09/2017
1	Emerging Communicable Diseases (Emerging Infectious Diseases) 09/2017
1	Acquired Immunodeficiency Syndrome (AIDS) 03/2017
1	Hepatitis C 03/2017
1	Intracranial Hypertension 04/2016
1	Traumatic Brain Injuries (Traumatic Brain Injury) 04/2016
1	Neurocognitive Disorders (Clerambault Syndrome) 12/2015
1	Cognitive Dysfunction 12/2015
1	Megaloblastic Anemia 06/2015
1	Urinary Bladder Neoplasms (Bladder Cancer) 01/2015
1	Prostatic Neoplasms (Prostate Cancer) 01/2015
1	Angiomyolipoma 01/2015
1	Sepsis (Septicemia) 10/2013
1	Acute Kidney Injury (Acute Renal Failure) 04/2013
1	Scoliosis 12/2011
1	Headache (Headaches) 07/2011
1	Aneurysm (Aneurysms) 07/2011
1	Migraine Disorders (Migraine) 07/2011
1	Wounds and Injuries (Trauma) 01/2011
1	Chronic Renal Insufficiency 01/2011
1	Substance-Related Disorders (Drug Abuse) 12/2006

Drug/Important Bio-Agent (IBA)

12	Opioid Analgesics (Opioids)IBA 10/2021 - 12/2003
12	Methadone (Dolophine)FDA LinkGeneric 01/2020 - 05/2004
9	Biomarkers (Surrogate Marker)IBA 12/2019 - 05/2010
6	Analgesics (Analgesic Drugs)IBA 01/2021 - 09/2009
6	Perilipin-2IBA 12/2019 - 05/2010
5	Fentanyl (Sublimaze)FDA LinkGeneric 01/2020 - 03/2004
5	Buprenorphine (Subutex)FDA LinkGeneric 01/2019 - 12/2006
4	Pharmaceutical PreparationsIBA 04/2016 - 12/2003
4	Proteins (Proteins, Gene)FDA Link 05/2015 - 12/2005
4	Cytochrome P-450 CYP3AIBA 10/2005 - 03/2003
3	CreatinineIBA 01/2015 - 12/2005
3	Morphine (MS Contin)FDA LinkGeneric 10/2013 - 12/2003
3	Alfentanil (Alfenta)FDA LinkGeneric 10/2005 - 03/2003
3	Quinidine (Chinidin)FDA LinkGeneric 05/2004 - 12/2003
2	Cytochrome P-450 CYP2B6 (CYP2B6)IBA 01/2020 - 06/2010
2	fenobamIBA 01/2020 - 09/2009
2	Midazolam (Versed)FDA LinkGeneric 04/2016 - 10/2005
2	Aquaporin 1IBA 01/2015 - 05/2013
2	Cyclosporine (Ciclosporin)FDA LinkGeneric 12/2014 - 10/2013
2	Lipocalin-2IBA 04/2013 - 01/2011
2	Sevoflurane (Ultane)FDA LinkGeneric 12/2005 - 09/2002
1	Ketamine FDA LinkGeneric 04/2021
1	Antidepressive Agents (Antidepressants)IBA 04/2021
1	5-HT3 Serotonin Receptors (5 HT3 Receptor)IBA 01/2021
1	Ondansetron (Zofran)FDA LinkGeneric 01/2021
1	Capsaicin (Zostrix)FDA Link 01/2020
1	Indicators and Reagents (Reagents)IBA 12/2019
1	efavirenz (Sustiva)FDA Link 10/2019
1	Carbon DioxideIBA 01/2019
1	Remifentanil (Ultiva)FDA Link 01/2019
1	Naphazoline (All Clear)FDA LinkGeneric 01/2019
1	Lidocaine (Xylocaine)FDA LinkGeneric 07/2018
1	zika virus NS1 proteinIBA 09/2017
1	ElementsIBA 09/2017
1	Immunoglobulin G (IgG)IBA 09/2017
1	Immunoglobulin M (IgM)IBA 09/2017
1	Nitrous Oxide (Laughing Gas)IBA 06/2015
1	Ritonavir (Norvir)FDA Link 09/2014
1	HIV Protease InhibitorsIBA 09/2014
1	Tumor Biomarkers (Tumor Markers)IBA 01/2014
1	Anesthetics (Anesthetic Agents)IBA 10/2013
1	norbuprenorphineIBA 10/2012
1	Bupropion (Wellbutrin)FDA LinkGeneric 06/2010
1	hydroxybupropionIBA 06/2010
1	Formaldehyde (Formol)FDA Link 09/2009
1	Nelfinavir (Viracept)FDA Link 05/2009

Therapy/Procedure

6	Therapeutics 10/2019 - 02/2005
6	Analgesia 12/2014 - 09/2004
2	Nephrectomy 01/2019 - 01/2011
2	Anesthesia 12/2011 - 09/2002
1	Ambulatory Surgical Procedures (Outpatient Surgery) 01/2019
1	Nerve Block (Nerve Blocks) 07/2018
1	Highly Active Antiretroviral Therapy (HAART) 12/2015
1	Operative Surgical Procedures 12/2011
1	Spinal Fusion (Spondylosyndesis) 12/2011
1	Length of Stay 12/2011
1	Stents 07/2011